Amphithéâtre Guillaume Budé, Site Marcelin Berthelot
En libre accès, dans la limite des places disponibles
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Résumé

Environmental factors during early life are critical for the Jater metabolic health of the individual and of future progeny. Using a mouse model of maternal calorie restriction during pregnancy affecting the metabolic physiology of two generations including paternal transmission to the second generation, we explore whether the mechanism by which paternal experience of in utero undemutrition impacts his offspring via perturbed methylation in his sperm.

Intervenant(s)

Anne Ferguson-Smith

University of Cambridge, Dept. of Physiology, Development and neuroscience, Cambridge, UK